K-Patents在制药和生化行业的应用

6.01.00 制药工艺

6.01.01 维生素B-2生产工艺
6.01.02 阿司匹林结晶
6.01.03 疫苗生产工艺
6.01.04 蛋白浓缩和膜渗滤

6.02.00 生化工艺

6.02.01 味精 (MSG) 结晶
6.02.02 赖氨酸蒸发工艺

 

6.01.00 Pharmaceutical Processing:

Overview of Process Control
Ref. 6.01.00 Pharmaceutical Processing (pdf)

6.01.01 Vitamin B-2 Production Process:

Ca-Arabonate is used to manufacture Vitamin B-2, Riboflavin. Corn is converted into glucose, which is then oxidized and purified by an ion-exchanger into Ca-Arabonate. Ca-Arabonate is precipitated and separated by centrifugation, then dissolved in water before further processing it into Vitamin B-2.
Ref. 6.01.01 Vitamin B-2 Production Process (pdf)

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6.01.02 Aspirin Crystallization:

Aspirin is the most widely sold over-the-counter drug. The production process involves the reaction of Salicylic acid and acetic anhydride in glass lined vessels. The liquid produced is pumped to a crystallizer, where it is cooled down to start the crystallization to Aspirin. The Aspirin is then filtered to remove the acetic acid and solvent, which are recovered and possibly recycled. The crystals are then washed and filtered again. The crystals are sent to sifting, granulating and tableting after drying.
Ref. 6.01.02 Aspirin Crystallization (pdf)

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6.01.03 Vaccine Production Process:

The viral vaccines are either produced by inoculating viruses into specific pathogen-free eggs or in animal cell culture based process. The allantoic fluid of these processes is harvested and purified by centrifugation and stabilised with buffer containing sucrose.
Ref. 6.01.03 Vaccine Production Process (pdf)

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6.01.04 Protein Concentration and Diafiltration:

Diafiltration is a technique using ultrafiltration (UF) membranes to separate the components of solutions and suspensions based on their molecular size, although other factors such as molecular shape and charge can also play a role.

Ref. 6.01.04 Protein Concentration and Diafiltration (pdf)

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6.02.01 Monosodium Glutamate (MSG) Crystallization:

Monosodium glutamate, more commonly referred to as MSG, is a sodium salt (C5H8NNaO4) of the non-essential amino acid glutamic acid. It is used to intensify the natural flavor of meats and vegetables.
Ref. 6.02.01 Monosodium Glutamate (MSG) Crystallization (pdf)

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6.02.02 L-Lysine Evaporation Process:

L-Lysine evaporation process is the process of producing microbially fermented amino acid commonly used for a variety of industrial use, such as feed additive, food material and health supplements. L-Lysine is essential for human and animal nutrition.
Ref. 6.02.02 L-Lysine Evaporation Process (pdf)

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